Deficiency of Transcription Factor Sp1 Contributes to Hypertrophic Cardiomyopathy.

Fulei ZhangHuixing ZhouJinfeng XueYuemei ZhangLiping ZhouJunwei LengGuojian FangYuanyuan LiuYan WangHongyu LiuYahan WuLingbin QiRan DuanXiaoyu HeYan WangYi LiuLi LiJian Yang Dandan Liang Yi-Han Chen

Published in: Circulation research (2024)

Our study demonstrates that SP1 deficiency leads to HCM. SP1 overexpression exhibits significant therapeutic effects on both HCM mice and HCM hiPSC-CMs, suggesting that SP1 could be a potential intervention target for HCM.

Keyphrases

hypertrophic cardiomyopathy
left ventricular
transcription factor
randomized controlled trial
heart failure
cell proliferation
type diabetes
replacement therapy
skeletal muscle
risk assessment
human health
atrial fibrillation
insulin resistance