Sex-specific association of visceral and subcutaneous adipose tissue volumes with systemic inflammation and innate immune cells in people living with obesity.
Inge Christina Lamberta van den MunckhofHarsh BahrarKiki SchraaTessa BrandRob Ter HorstMarinette van der GraafHelena M DekkerRinke StienstraJacqueline de GraafLeo A B JoostenMihai M NeteaNiels P RiksenJoseph Henricus Wilhelmus RuttenPublished in: International journal of obesity (2005) (2023)
In women living with obesity, abdominal SAT volume, especially sSAT, is associated with circulating leukocytes and inflammatory proteins. In men, these parameters mainly show associations with VAT volume. This could be because only in women, sSAT volume is associated with sSAT expression of inflammatory proteins. These findings underscore that future research on adipose tissue in relation to cardiometabolic and cardiovascular disease should take sex differences into account.
Keyphrases
- insulin resistance
- adipose tissue
- polycystic ovary syndrome
- cardiovascular disease
- innate immune
- high fat diet
- metabolic syndrome
- type diabetes
- high fat diet induced
- weight loss
- induced apoptosis
- oxidative stress
- skeletal muscle
- poor prognosis
- weight gain
- pregnancy outcomes
- cell cycle arrest
- pregnant women
- cervical cancer screening
- signaling pathway
- coronary artery disease
- cardiovascular events
- endoplasmic reticulum stress
- cell death
- cardiovascular risk factors