Antagonistic Roles of Human Platelet Integrin αIIbβ3 and Chemokines in Regulating Neutrophil Activation and Fate on Arterial Thrombi Under Flow.
Claudia SchönichenSamantha J MontagueSanne L N BrounsJames J BurstonJudith M E M CosemansKerstin JurkBeate E KehrelRory R KoenenFionnuala Ní ÁinleValerie B O'DonnellOliver SoehnleinStephen P WatsonMarijke J E KuijpersJohan W M HeemskerkMagdolna NagyPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
Together, these findings reveal a multifaceted regulation of adhesion and activation of neutrophils by platelets in a thrombus, with a balanced role of several platelet-adhesive receptors and a promoting role of platelet-released substances. This multivalent nature of neutrophil-thrombus interactions offers novel prospects for pharmacological intervention.