Johan W M Heemskerk (Johan Wm Heemskerk)

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 46

Top Topics

Tyrosine Kinase

Venous Thromboembolism

Top Venues

International journal of molecular sciences

Thrombosis and haemostasis

Cellular and molecular life sciences : CMLS

This page only lists publications with an associated author ORCID identifier.

Publications

Isabella Provenzale, Fiorella Andrea Solari, Claudia Schönichen, Sanne L N Brouns, Delia I Fernández, Marijke J E Kuijpers, Paola E J van der Meijden, Jonathan M Gibbins, Albert Sickmann, Chris Jones, Johan W M Heemskerk
Endothelium-mediated regulation of platelet activation: Involvement of multiple protein kinases. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 38 (4) (2024)
Natalie J Jooss, Marije G Diender, Delia I Fernández, Jingnan Huang, Floor C J Heubel-Moenen, Arian van der Veer, Marijke J E Kuijpers, Natalie S Poulter, Yvonne M C Henskens, Maroeska Te Loo, Johan W M Heemskerk
Restraining of glycoprotein VI- and integrin α2β1-dependent thrombus formation by platelet PECAM1. Cellular and molecular life sciences : CMLS 81 (1) (2024)
Pengyu Zhang, Saskia von Ungern-Sternberg, Luisa Hastenplug, Fiorella Solari, Albert Sickmann, Marijke J E Kuijpers, Johan W M Heemskerk, Ulrich Walter, Kerstin Jurk
Multi-phased kinetics and interaction of protein kinase signaling in glycoprotein VI-induced platelet αIIbβ3 integrin activation and degranulation. Thrombosis and haemostasis (2024)
Natalie J Jooss, Marije G Diender, Delia I Fernández, Jingnan Huang, Floor C J Heubel-Moenen, Arian van der Veer, Marijke J E Kuijpers, Natalie S Poulter, Yvonne M C Henskens, Maroeska Te Loo, Johan W M Heemskerk
Restraining of glycoprotein VI- and integrin α2β1-dependent thrombus formation by platelet PECAM1. Cellular and molecular life sciences : CMLS 81 (1) (2024)
Pengyu Zhang, Saskia von Ungern-Sternberg, Luisa Hastenplug, Fiorella A Solari, Albert Sickmann, Marijke J E Kuijpers, Johan W M Heemskerk, Ulrich Walter, Kerstin Jurk
Multi-phased Kinetics and Interaction of Protein Kinase Signaling in Glycoprotein VI-Induced Platelet αIIbβ3 Integrin Activation and Degranulation. Thrombosis and haemostasis (2024)
Natalie J Jooss, Marije G Diender, Delia I Fernández, Jingnan Huang, Floor C J Heubel-Moenen, Arian van der Veer, Marijke J E Kuijpers, Natalie S Poulter, Yvonne M C Henskens, Maroeska Te Loo, Johan W M Heemskerk
Restraining of glycoprotein VI- and integrin α2β1-dependent thrombus formation by platelet PECAM1. Cellular and molecular life sciences : CMLS 81 (1) (2024)
Isabella Provenzale, Fiorella Andrea Solari, Claudia Schönichen, Sanne L N Brouns, Delia I Fernández, Marijke J E Kuijpers, Paola E J van der Meijden, Jonathan M Gibbins, Albert Sickmann, Chris Jones, Johan W M Heemskerk
Endothelium-mediated regulation of platelet activation: Involvement of multiple protein kinases. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 38 (4) (2024)
Delia Irene Fernández, Isabella Provenzale, Matthias Canault, Salome Fels, Antonia Lenz, Felicia Andresen, Anne Krümpel, Arnaud Dupuis, Johan W M Heemskerk, Doris Boeckelmann, Barbara Maria Hildegard Zieger
High-throughput microfluidic blood testing to phenotype genetically linked platelet disorders: an aid to diagnosis. Blood advances (2023)
Claudia Schönichen, Samantha J Montague, Sanne L N Brouns, James J Burston, Judith M E M Cosemans, Kerstin Jurk, Beate E Kehrel, Rory R Koenen, Fionnuala Ní Áinle, Valerie B O'Donnell, Oliver Soehnlein, Stephen P Watson, Marijke J E Kuijpers, Johan W M Heemskerk, Magdolna Nagy
Antagonistic Roles of Human Platelet Integrin αIIbβ3 and Chemokines in Regulating Neutrophil Activation and Fate on Arterial Thrombi Under Flow. Arteriosclerosis, thrombosis, and vascular biology (2023)
Pengyu Zhang, Fiorella Andrea Solari, Johan W M Heemskerk, Marijke J E Kuijpers, Albert Sickmann, Ulrich Walter, Kerstin Jurk
Differential Regulation of GPVI-Induced Btk and Syk Activation by PKC, PKA and PP2A in Human Platelets. International journal of molecular sciences 24 (9) (2023)
Natalie J Jooss, Yvonne M C Henskens, Steve P Watson, Richard W Farndale, Meinrad P Gawaz, Martine Jandrot-Perrus, Natalie S Poulter, Johan W M Heemskerk
Pharmacological Inhibition of Glycoprotein VI- and Integrin α2β1-Induced Thrombus Formation Modulated by the Collagen Type. Thrombosis and haemostasis (2023)
Hippolyte Verdier, Patrick Thomas, Joana Batista, Carly Kempster, Harriet McKinney, Nicholas S Gleadall, John Danesh, Andrew D Mumford, Johan W M Heemskerk, Willem Hendrik Ouwehand, Kate Downes, William John Astle, Ernest Turro
A signature of platelet reactivity in CBC scattergrams reveals genetic predictors of thrombotic disease risk. Blood (2023)
Sanjeev Kiran Gotru, Elmina Mammadova-Bach, Georgios Sogkas, Michael K Schuhmann, Karen Schmitt, Peter Kraft, Sabine Herterich, Medina Mamtimin, Akif Pinarci, Sarah Beck, Simon Stritt, Han Chao, Pengxuan Ren, Jean-Noël Freund, Christian Klemann, Felix C C Ringshausen, Johan W M Heemskerk, Alexander Dietrich, Bernhard Nieswandt, Guido Stoll, Thomas Gudermann, Attila Braun
MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice. Arteriosclerosis, thrombosis, and vascular biology (2023)
Natalie J Jooss, Yvonne M C Henskens, Steve P Watson, Richard W Farndale, Meinrad P Gawaz, Martine Jandrot-Perrus, Natalie S Poulter, Johan W M Heemskerk
Pharmacological Inhibition of Glycoprotein VI- and Integrin α2β1-Induced Thrombus Formation Modulated by the Collagen Type. Thrombosis and haemostasis (2023)
Isabella Provenzale, Ilaria De Simone, Jonathan M Gibbins, Johan W M Heemskerk, Paola E J van der Meijden, Chris I Jones
Regulation of Glycoprotein VI-Dependent Platelet Activation and Thrombus Formation by Heparan Sulfate Proteoglycan Perlecan. International journal of molecular sciences 24 (17) (2023)
Pengyu Zhang, Fiorella Andrea Solari, Johan W M Heemskerk, Marijke J E Kuijpers, Albert Sickmann, Ulrich Walter, Kerstin Jurk
Differential Regulation of GPVI-Induced Btk and Syk Activation by PKC, PKA and PP2A in Human Platelets. International journal of molecular sciences 24 (9) (2023)
Siyu Sun, Elena Campello, Jinmi Zou, Joke Konings, Dana Huskens, Jun Wan, Delia Irene Fernández, Chris P M Reutelingsperger, Hugo Ten Cate, Serena Toffanin, Cristiana Bulato, Philip G de Groot, Bas de Laat, Paolo Simioni, Johan W M Heemskerk, Mark Roest
Crucial roles of red blood cells and platelets in whole blood thrombin generation. Blood advances (2023)
Jingnan Huang, Johan W M Heemskerk, Frauke Swieringa
Combining human platelet proteomes and transcriptomes: possibilities and challenges. Platelets 34 (1) (2023)
Pengyu Zhang, Fiorella Andrea Solari, Johan W M Heemskerk, Marijke J E Kuijpers, Albert Sickmann, Ulrich Walter, Kerstin Jurk
Differential Regulation of GPVI-Induced Btk and Syk Activation by PKC, PKA and PP2A in Human Platelets. International journal of molecular sciences 24 (9) (2023)
Ilaria De Simone, Constance C F M J Baaten, Martine Jandrot Perrus, Jonathan M Gibbins, Hugo Ten Cate, Johan W M Heemskerk, Chris I Jones, Paola E J van der Meijden
Coagulation Factor XIIIa and Activated Protein C Activate Platelets via GPVI and PAR1. International journal of molecular sciences 23 (18) (2022)
Alicia Veninga, Stefan Handtke, Konstanze Aurich, Bibian M E Tullemans, Sanne L N Brouns, Silas L Schwarz, Floor C J I Heubel-Moenen, Andreas Greinacher, Johan W M Heemskerk, Paola E J van der Meijden, Thomas Thiele
GPVI expression is linked to platelet size, age, and reactivity. Blood advances 6 (14) (2022)
Linsey J F Peters, Constance C F M J Baaten, Sanne L Maas, Chang Lu, Magdolna Nagy, Natalie J Jooss, Kiril Bidzhekov, Donato Santovito, Daniel Moreno-Andres, Joachim Jankowski, Erik A L Biessen, Yvonne Döring, Johan W M Heemskerk, Christian Weber, Marijke J E Kuijpers, Emiel P.C. van der Vorst
MicroRNA-26b Attenuates Platelet Adhesion and Aggregation in Mice. Biomedicines 10 (5) (2022)
Johana Hrdinova, Delia Irene Fernández, Bogac Ercig, Bibian M E Tullemans, Dennis P L Suylen, Stijn M Agten, Kerstin Jurk, Tilman M Hackeng, Karen Vanhoorelbeke, Jan Voorberg, Chris P M Reutelingsperger, Kanin Wichapong, Johan W M Heemskerk, Gerry A F Nicolaes
Structure-Based Cyclic Glycoprotein Ibα-Derived Peptides Interfering with von Willebrand Factor-Binding, Affecting Platelet Aggregation under Shear. International journal of molecular sciences 23 (4) (2022)
Sanne L N Brouns, Bibian M E Tullemans, Cristiana Bulato, Gina Perrella, Elena Campello, Spiezia Luca, Johanna P van Geffen, Marijke J E Kuijpers, René van Oerle, Henri M H Spronk, Paola E J van der Meijden, Paolo Simioni, Johan W M Heemskerk
Protein C or Protein S deficiency associates with paradoxically impaired platelet-dependent thrombus and fibrin formation under flow. Research and practice in thrombosis and haemostasis 6 (2) (2022)
Jinmi Zou, Frauke Swieringa, Bas de Laat, Philip G de Groot, Mark Roest, Johan W M Heemskerk
Reversible Platelet Integrin αIIbβ3 Activation and Thrombus Instability. International journal of molecular sciences 23 (20) (2022)
Yam Fung Hilaire Cheung, Luis A Moran, Albert Sickmann, Johan W M Heemskerk, Angel Garcia, Stephen P Watson
Inhibition of Src but not Syk causes weak reversal of GPVI-mediated platelet aggregation measured by light transmission aggregometry. Platelets 33 (8) (2022)
Jingnan Huang, Natalie J Jooss, Delia Irene Fernández, Albert Sickmann, Angel Garcia, Kanin Wichapong, Ingrid Dijkgraaf, Johan W M Heemskerk
Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent Thrombus Formation under Shear. International journal of molecular sciences 23 (15) (2022)
Katrin Nitz, Michael Lacy, Mariaelvy Bianchini, Kanin Wichapong, Irem Avcilar Kücükgöze, Cecilia A Bonfiglio, Roberta Migheli, Yuting Wu, Carina Burger, Yuanfang Li, Ignasi Forne, Constantin Ammar, Aleksandar Janjic, Sarajo Mohanta, Johan Duchene, Johan W M Heemskerk, Remco T A Megens, Edzard Schwedhelm, Stephan Huveneers, Craig A Lygate, Donato Santovito, Ralf Zimmer, Axel Imhof, Christian Weber, Esther Lutgens, Dorothee Atzler
The Amino Acid Homoarginine Inhibits Atherogenesis by Modulating T-Cell Function. Circulation research 131 (8) (2022)
Julian Leberzammer, Stijn M Agten, Xavier Blanchet, Rundan Duan, Hans Ippel, Remco T A Megens, Christian Schulz, Maria Aslani, Johan Duchene, Yvonne Döring, Natalie J Jooss, Pengyu Zhang, Richard Brandl, Konstantin Stark, Wolfgang Siess, Kerstin Jurk, Johan W M Heemskerk, Tilman M Hackeng, Kevin H Mayo, Christian Weber, Philipp von Hundelshausen
Targeting platelet-derived CXCL12 impedes arterial thrombosis. Blood 139 (17) (2022)
Stefano Navarro, Andreas Starke, Johan W M Heemskerk, Marijke J E Kuijpers, David Stegner, Bernhard Nieswandt
Targeting of a Conserved Epitope in Mouse and Human GPVI Differently Affects Receptor Function. International journal of molecular sciences 23 (15) (2022)
Herm Jan M Brinkman, Frauke Swieringa, Marleen Zuurveld, Alicia Veninga, Sanne L N Brouns, Johan W M Heemskerk, Joost C M Meijers
Reversing direct factor Xa or thrombin inhibitors: Factor V addition to prothrombin complex concentrate is beneficial in vitro. Research and practice in thrombosis and haemostasis 6 (3) (2022)
Johan W M Heemskerk
More than reverting tyrosine kinases. Blood 140 (9) (2022)
Gina Perrella, Samantha J Montague, Helena C Brown, Lourdes Garcia Quintanilla, Alexandre Slater, David Stegner, Mark Thomas, Johan W M Heemskerk, Steve P Watson
Role of Tyrosine Kinase Syk in Thrombus Stabilisation at High Shear. International journal of molecular sciences 23 (1) (2022)
Marijke J E Kuijpers, Johan W M Heemskerk, Kerstin Jurk
Molecular Mechanisms of Hemostasis, Thrombosis and Thrombo-Inflammation. International journal of molecular sciences 23 (10) (2022)
Natalie J Jooss, Christopher W Smith, Alexandre Stephane Slater, Samantha J Montague, Ying Di, Christopher O'Shea, Mark R Thomas, Yvonne M C Henskens, Johan W M Heemskerk, Stephen P Watson, Natalie S Poulter
Anti-GPVI nanobody blocks collagen- and atherosclerotic plaque-induced GPVI clustering, signaling, and thrombus formation. Journal of thrombosis and haemostasis : JTH 20 (11) (2022)
Gina Perrella, Magdolna Nagy, Stephen P Watson, Johan W M Heemskerk
Platelet GPVI (Glycoprotein VI) and Thrombotic Complications in the Venous System. Arteriosclerosis, thrombosis, and vascular biology 41 (11) (2021)
Stefano Navarro, David Stegner, Bernhard Nieswandt, Johan W M Heemskerk, Marijke J E Kuijpers
Temporal Roles of Platelet and Coagulation Pathways in Collagen- and Tissue Factor-Induced Thrombus Formation. International journal of molecular sciences 23 (1) (2021)
Jingnan Huang, Pengyu Zhang, Fiorella Andrea Solari, Albert Sickmann, Angel Garcia, Kerstin Jurk, Johan W M Heemskerk
Molecular Proteomics and Signalling of Human Platelets in Health and Disease. International journal of molecular sciences 22 (18) (2021)
Jinmi Zou, Jiayu Wu, Mark Roest, Johan W M Heemskerk
Long-term platelet priming after glycoprotein VI stimulation in comparison to Protease-Activating Receptor (PAR) stimulation. PloS one 16 (3) (2021)
Bibian M E Tullemans, Alicia Veninga, Delia Irene Fernández, Maureen J B Aarts, Johannes Andreas Eble, Paola E J van der Meijden, Johan W M Heemskerk, Marijke J E Kuijpers
Multiparameter Evaluation of the Platelet-Inhibitory Effects of Tyrosine Kinase Inhibitors Used for Cancer Treatment. International journal of molecular sciences 22 (20) (2021)
Michael Lacy, Christina Bürger, Annelie Shami, Maiwand Ahmadsei, Holger Winkels, Katrin Nitz, Claudia M van Tiel, Tom T P Seijkens, Pascal J H Kusters, Ela Karshovka, Koen H M Prange, Yuting Wu, Sanne L N Brouns, Sigrid Unterlugauer, Marijke J E Kuijpers, Myrthe E Reiche, Sabine Steffens, Andreas Edsfeldt, Remco T A Megens, Johan W M Heemskerk, Isabel Goncalves, Christian Weber, Norbert Gerdes, Dorothee Atzler, Esther Lutgens
Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease. Nature communications 12 (1) (2021)
Fraser L Macrae, Frauke Swieringa, Johan W M Heemskerk, Robert A S Ariëns
High fibrinogen γ' levels in patient plasma increase clot formation at arterial and venous shear. Blood advances 5 (17) (2021)
Funda Tamer, Bibian Tullemans, Marijke J E Kuijpers, Dorith Claushuis, Johan W M Heemskerk
Nutrition phytochemicals affecting platelet signaling and responsiveness: implications for thrombosis and hemostasis. Thrombosis and haemostasis (2021)
Alicia Veninga, Constance C F M J Baaten, Ilaria De Simone, Bibian M E Tullemans, Marijke J E Kuijpers, Johan W M Heemskerk, Paola E J van der Meijden
Effects of Platelet Agonists and Priming on the Formation of Platelet Populations. Thrombosis and haemostasis (2021)
Siyu Sun, Rolf T Urbanus, Hugo Ten Cate, Philip G de Groot, Bas de Laat, Johan W M Heemskerk, Mark Roest
Platelet Activation Mechanisms and Consequences of Immune Thrombocytopenia. Cells 10 (12) (2021)
Delia Irene Fernández, Marijke J E Kuijpers, Johan W M Heemskerk
Platelet calcium signaling by G-protein coupled and ITAM-linked receptors regulating anoctamin-6 and procoagulant activity. Platelets 32 (7) (2020)