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The Role of Platelet Rich Plasma in Vertebrogenic and Discogenic Pain: A Systematic Review and Meta-Analysis.

Saurabh KatariaJeremiah Hilkiah WijayaUtsav PatelKevin YabutTawfiq TurjmanMuhammad Abubakar AyubNihar UpadhyayMoinulhaq MakraniHisham TurjmanAhmed Mostafa Abdalla MohamedAlan David Kaye
Published in: Current pain and headache reports (2024)
Back pain is a common and significant condition that affects millions of people around the world. The cause of back pain is often complex and multifactorial, with discogenic and vertebrogenic pain being two subtypes of back pain. Currently, there are numerous methods and modalities in which back pain is managed and treated such as physical therapy, electrical nerve stimulation, pharmacotherapies, and platelet-rich plasma. To conduct this systematic review, the authors used the keywords "platelet-rich plasma", "vertebrogenic pain", and "discogenic pain", on PubMed, EuroPMC, Who ICTRP, and clinicaltrials.gov to better elucidate the role of this treatment method for combating vertebrogenic and discogenic back pain. In recent decades, there has been a rise in popularity of the use of platelet-rich plasma for the treatment of numerous musculoskeletal conditions. Related to high concentration of platelets, growth factors, cytokines, and chemokines, platelet-rich plasma is effective in reducing pain related symptoms and in the treatment of back pain. Platelet-rich plasma use has evolved and gained popularity for pain related conditions, including vertebrogenic and discogenic back pain. Additional well-designed studies are warranted in the future to better determine best practice strategies to provide future clinicians with a solid foundation of evidence to make advancements with regenerative medical therapies such as platelet-rich plasma.
Keyphrases
  • platelet rich plasma
  • chronic pain
  • pain management
  • neuropathic pain
  • systematic review
  • stem cells
  • primary care
  • combination therapy
  • randomized controlled trial
  • current status
  • newly diagnosed