The effects of enoxaparin treatment in a xenograft mouse model of oral squamous cell carcinoma: A pilot study.
Yeliz EkiciMerva Soluk TekkeşinUmut Can KüçüksezerHazal Banu Olgun CelebiogluErman Bulent TuncerElcin BedelogluFeyza Nur TuncerPublished in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2024)
Reduced BCL-2 expression indicates a regression of tumor growth, but reduced BAX expression is not correlated with increased apoptosis. Despite the aggressive nature of OSC-19, our results showed a low cell viability with a high division rate when compared with the control HEK293. This paralleled our in vivo findings that showed absence of lymph node metastasis across all mice groups. This discrepancy with the literature suggests that further investigations of the underlying mechanisms and protein-level analyses are needed to draw definitive conclusions about the effect of enoxaparin on OSC-19 behavior.
Keyphrases
- lymph node metastasis
- poor prognosis
- mouse model
- venous thromboembolism
- binding protein
- squamous cell carcinoma
- systematic review
- oxidative stress
- papillary thyroid
- endoplasmic reticulum stress
- cell death
- type diabetes
- long non coding rna
- locally advanced
- induced apoptosis
- metabolic syndrome
- insulin resistance
- small molecule
- amino acid
- rectal cancer