Validation of In Vivo Nodal Assessment of Solid Malignancies with USPIO-Enhanced MRI: A Workflow Protocol.
Daphne A J J DriessenDidi J J M de GouwRutger C H StijnsGeke LitjensBas IsraëlBart W J PhilipsJohn J HermansTim DijkemaBastiaan R KlarenbeekRachel S van der PostIris D NagtegaalAdriana C H van Engen-van GrunsvenLodewijk A A BrosensAndor VeltienPatrik ZámecnikTom W J ScheenenPublished in: Methods and protocols (2022)
A workflow was developed to validate in vivo USPIO-enhanced MRI with histopathology. Guiding the pathologist towards lymph nodes in the resection specimens during histopathological work-up allowed for the analysis at a nodal basis, or at least nodal station basis, of in vivo suspicious lymph nodes with corresponding histopathology, providing direct information for validation of in vivo USPIO-enhanced, MRI-detected lymph nodes.