Ventral posterior substantia nigra iron increases over 3 years in Parkinson's disease.

Niels P BergslandRobert ZivadinovFerdinand SchweserJesper HagemeierDavid LichterThomas Guttuso

Published in: Movement disorders : official journal of the Movement Disorder Society (2019)

We found both cross-sectional and longitudinal SN iron changes to be confined to its more ventral location in PD. Because pathology studies also show the ventral SN to degenerate early and to the greatest extent in PD, the assessment of iron levels by quantitative susceptibility mapping in this area may potentially represent a disease progression biomarker in PD. © 2019 International Parkinson and Movement Disorder Society.

Keyphrases

cross sectional
spinal cord
deep brain stimulation
iron deficiency
prefrontal cortex
high resolution
spinal cord injury
case control