Sirtuin 3-mediated deacetylation of acyl-CoA synthetase family member 3 by protocatechuic acid attenuates non-alcoholic fatty liver disease.

Ruimin SunXiaohui KangYan ZhaoZhanyu WangRuiwen WangRong FuYang LiYan HuZhecheng WangWen ShanJunjun ZhouXiaofeng TianJihong Yao

Published in: British journal of pharmacology (2020)

SIRT3-mediated ACSF3 deacetylation is a novel molecular mechanism in NAFLD therapy and protocatechuic acid confers protection against high-fat diet- and palmitic acid-induced hepatic fatty acid metabolism disorder through the SIRT3/ACSF3 pathway.

Keyphrases

high fat diet
fatty acid
insulin resistance
adipose tissue
oxidative stress
ischemia reperfusion injury