Cytoplasmic Polyadenylation Element Binding Protein 1 and Atherosclerosis: Prospective Target and New Insights.
Jing ZhouChao-Ke TangPublished in: Current vascular pharmacology (2024)
The ribonucleic acid (RNA)-binding protein Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1), a key member of the CPEB family, is essential in controlling gene expression involved in both healthy physiological and pathological processes. CPEB1 can bind to the 3'- untranslated regions (UTR) of substrate messenger ribonucleic acid (mRNA) and regulate its translation. There is increasing evidence that CPEB1 is closely related to the pathological basis of atherosclerosis. According to recent investigations, many pathological processes, including inflammation, lipid metabolism, endothelial dysfunction, angiogenesis, oxidative stress, cellular senescence, apoptosis, and insulin resistance, are regulated by CPEB1. This review considers the prevention and treatment of atherosclerotic heart disease in relation to the evolution of the physiological function of CPEB1, recent research breakthroughs, and the potential participation of CPEB1 in atherosclerosis.
Keyphrases
- binding protein
- oxidative stress
- gene expression
- cardiovascular disease
- insulin resistance
- dna damage
- endothelial cells
- adipose tissue
- endoplasmic reticulum stress
- physical activity
- cell death
- high fat diet
- pulmonary hypertension
- combination therapy
- risk assessment
- cell cycle arrest
- heat shock protein
- heat shock
- fatty acid
- high fat diet induced
- smoking cessation