Mesenchymal-epithelial transition in development and reprogramming.

Duan-Qing PeiXiaodong ShuAma Gassama-DiagneJean-Paul Thiery

Published in: Nature cell biology (2019)

During organogenesis, epithelial cells can give rise to mesenchymal cells through epithelial-mesenchymal transition. The reverse process, mesenchymal-epithelial transition (MET), can similarly generate epithelial cells. Transitions between epithelial and mesenchymal states are also critical for the induction of pluripotent stem cells from somatic cells. This Review discusses the relatively less characterized process of MET, focusing on the genesis of apicobasal cell polarity and exploring the roles of MET in development and reprogramming.

Keyphrases

bone marrow
induced apoptosis
stem cells
epithelial mesenchymal transition
cell cycle arrest
tyrosine kinase
signaling pathway
pluripotent stem cells
single cell
oxidative stress
endoplasmic reticulum stress
cell death
transforming growth factor
cell proliferation
copy number
pi k akt