Immunotherapies against HER2-Positive Breast Cancer.
Santiago Duro-SánchezMacarena Román AlonsoJoaquín ArribasPublished in: Cancers (2023)
Breast cancer is the leading cause of cancer-related deaths among women worldwide. HER2-positive breast cancer, which represents 15-20% of all cases, is characterized by the overexpression of the HER2 receptor. Despite the variety of treatments available for HER2-positive breast cancer, both targeted and untargeted, many patients do not respond to therapy and relapse and eventually metastasize, with a poor prognosis. Immunotherapeutic approaches aim to enhance the antitumor immune response to prevent tumor relapse and metastasis. Several immunotherapies have been approved for solid tumors, but their utility for HER2-positive breast cancer has yet to be confirmed. In this review, we examine the different immunotherapeutic strategies being tested in HER2-positive breast cancer, from long-studied cancer vaccines to immune checkpoint blockade, which targets immune checkpoints in both T cells and tumor cells, as well as the promising adoptive cell therapy in various forms. We discuss how some of these new approaches may contribute to the prevention of tumor progression and be used after standard-of-care therapies for resistant HER2-positive breast tumors, highlighting the benefits and drawbacks of each. We conclude that immunotherapy holds great promise for the treatment of HER2-positive tumors, with the potential to completely eradicate tumor cells and prevent the progression of the disease.
Keyphrases
- positive breast cancer
- cell therapy
- poor prognosis
- immune response
- long non coding rna
- stem cells
- ejection fraction
- mesenchymal stem cells
- healthcare
- palliative care
- quality improvement
- cell proliferation
- free survival
- polycystic ovary syndrome
- squamous cell carcinoma
- bone marrow
- prognostic factors
- type diabetes
- machine learning
- transcription factor
- pregnant women
- pain management
- high resolution
- chronic kidney disease
- combination therapy
- skeletal muscle
- deep learning
- patient reported outcomes
- high resolution mass spectrometry
- artificial intelligence
- childhood cancer
- binding protein
- gas chromatography mass spectrometry
- smoking cessation