MD2 deficiency prevents high-fat diet-induced AMPK suppression and lipid accumulation through regulating TBK1 in non-alcoholic fatty liver disease.

Wu LuoLin YeXue-Ting HuMei-Hong WangMin-Xiu WangLei-Ming JinZhong-Xiang XiaoJian-Chang QianYi WangWei ZuoLi-Jiang HuangGuang Liang

Published in: Clinical and translational medicine (2022)

Hepatocyte MD2 plays a pathogenic role in NAFLD through TBK1-AMPK/SREBP1 and lipid metabolism pathway. These studies provide new insight into a non-inflammatory function of MD2 and evidence for the important role of MD2 in NALFD.

Keyphrases

molecular dynamics
high fat diet induced
insulin resistance
skeletal muscle
metabolic syndrome
protein kinase
mouse model
case control