Characterization of ACE Inhibitors and AT1R Antagonists with Regard to Their Effect on ACE2 Expression and Infection with SARS-CoV-2 Using a Caco-2 Cell Model.

Philipp ReusAnn-Kathrin SchneiderThomas UlshöferMarina HenkeDenisa BojkovaJindrich CinatlSandra CiesekGerd GeisslingerVolker LauxMira GrättingerPhilip Gribbon Susanne Schiffmann

Published in: Life (Basel, Switzerland) (2021)

ACE inhibitors and AT1R antagonist showed neither beneficial nor detrimental effects on SARS-CoV-2-infection and cell barrier integrity in vitro at pharmacologically relevant concentrations.

Keyphrases

sars cov
angiotensin converting enzyme
angiotensin ii
single cell
cell therapy
poor prognosis
respiratory syndrome coronavirus
long non coding rna