Malva parviflora extract ameliorates the deleterious effects of a high fat diet on the cognitive deficit in a mouse model of Alzheimer's disease by restoring microglial function via a PPAR-γ-dependent mechanism.
Elisa Medrano-JiménezItzia Jiménez-Ferrer CarrilloMartha Pedraza-EscalonaCristina E Ramírez-SerranoLourdes Álvarez-ArellanoJavier Cortés-MendozaMaribel Herrera-RuizEnrique Jiménez-FerrerAlejandro ZamilpaJaime TortorielloGustavo Pedraza-AlvaLeonor Pérez-MartínezPublished in: Journal of neuroinflammation (2019)
M. parviflora suppresses neuroinflammation by inhibiting microglia pro-inflammatory M1 phenotype and promoting microglia phagocytosis. Therefore, M. parviflora phytochemicals represent an alternative to prevent cognitive impairment associated with a metabolic disorder as well as an effective prophylactic candidate for AD progression.
Keyphrases
- high fat diet
- cognitive impairment
- mouse model
- inflammatory response
- insulin resistance
- neuropathic pain
- lipopolysaccharide induced
- lps induced
- adipose tissue
- signaling pathway
- traumatic brain injury
- oxidative stress
- cognitive decline
- spinal cord injury
- metabolic syndrome
- skeletal muscle
- type diabetes
- fatty acid
- brain injury
- cerebral ischemia
- subarachnoid hemorrhage
- blood brain barrier