Mitochondria Permeability Transition versus Necroptosis in Oxalate-Induced AKI.

Shrikant Ramesh MulayMohsen M HonarpishehOrestes Foresto-NetoChongxu ShiJyaysi DesaiZhi Bo ZhaoJulian A MarschnerBastian PopperEwa Miriam BuhlPeter BoorAndreas LinkermannHelen LiapisRostyslav BilyyMartin HerrmannPaola RomagnaniIlya Belevich Eija S JokitaloJan U BeckerHans-Johachim Anders

Published in: Journal of the American Society of Nephrology : JASN (2019)

Mitochondrial permeability transition-related regulated necrosis and necroptosis both contribute to oxalate-induced AKI, identifying PPIF as a potential molecular target for renoprotective intervention.

Keyphrases

high glucose
acute kidney injury
diabetic rats
endothelial cells
randomized controlled trial
oxidative stress
drug induced
transcription factor
risk assessment
climate change