Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma.
Catherine A BehrmannKelli N EnnisPranjal SarmaCollin WetzelNicholas A ClarkKate M Von HandorfSubrahmanya VallabhapurapuCristina AndreaniJames ReiglePier Paolo ScaglioniJaroslaw MellerMaria F Czyzyk-KrzeskaAdy KendlerXiaoyang QiJann N SarkariaMario MedvedovicSoma SenguptaBiplab DasGuptaDavid R PlasPublished in: Cancer research communications (2024)
Therapy for glioblastoma would be advanced by incorporating molecularly targeted kinase-directed agents, similar to standard of care strategies in other tumor types. Here, we identify a kinase targeting approach to inhibit the metabolism and growth of glioblastoma.