Molecular Analysis in a Glioblastoma Cohort-Results of a Prospective Analysis.
Liverana LaurettiTonia CenciNicola MontanoMartina OffiMartina GiordanoValerio M CaccavellaAntonella MangravitiLudovico AgostiniAlessandro OliviLucia GabrieleLuigi Maria LaroccaRoberto PalliniMaurizio MartiniQuintino Giorgio D'AlessandrisPublished in: Journal of personalized medicine (2022)
The prognostic role of epidermal growth factor receptor variant III (EGFRvIII), a constitutively activated oncogenic receptor, in glioblastoma is controversial. We performed a prospective study enrolling 355 patients operated on for de novo glioblastoma at a large academic center. The molecular profile, including EGFRvIII status, MGMT promoter methylation, and VEGF expression, was assessed. Standard parameters (age, clinical status and extent of surgical resection) were confirmed to hold prognostic value. MGMT promoter methylation portended a slightly improved survival. In the whole series, confirming previous results, EGFRvIII was not associated with worsened prognosis. Interestingly, female sex was associated with a better outcome. Such findings are of interest for the design of future trials.
Keyphrases
- epidermal growth factor receptor
- dna methylation
- transcription factor
- end stage renal disease
- tyrosine kinase
- genome wide
- gene expression
- newly diagnosed
- ejection fraction
- advanced non small cell lung cancer
- poor prognosis
- chronic kidney disease
- endothelial cells
- peritoneal dialysis
- binding protein
- single molecule
- data analysis
- medical students