Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4.

Kathrine LundøOksana DmytriyevaLouise SpøhrEliana Goncalves-AlvesJiayi YaoLaia P BlascoMette TrauelsenMuthulakshmi PonniahMarc SeverinAlbin SandelinMarie KveiborgThue W Schwartz Stine Helene Falsig Pedersen

Published in: BMC cancer (2023)

GPR81 supports breast cancer aggressiveness, and in MCF-7 cells, this occurs at least in part via DLL4. Our findings reveal a new GPR81-driven mechanism in breast cancer and substantiate GPR81 as a promising treatment target.

Keyphrases

fatty acid
induced apoptosis
cell proliferation
breast cancer cells
breast cancer risk
gene expression
dna methylation
cell death
young adults
smoking cessation
pi k akt