Thiazolidinediones (TZDs) enhance insulin secretory response via GPR40 and adenylate cyclase (AC).

Mina HwangHyo-Sup KimSang-Man JinKyu Yeon HurJae-Hyeon KimMoon Kyu Lee

Published in: Journal of cellular physiology (2021)

Thiazolidinediones are synthetic PPARγ ligands that enhance insulin sensitivity, and that could increase insulin secretion from β-cells. However, the functional role and mechanism(s) of action in pancreatic β-cells have not been investigated in detail.

Keyphrases

induced apoptosis
cell cycle arrest
type diabetes
endoplasmic reticulum stress
fatty acid
adipose tissue
skeletal muscle
weight loss