A novel flavonoid derivative of icariside II improves erectile dysfunction in a rat model of cavernous nerve injury.

Sheng-Ji GuMeng LiYi-Ming YuanZhong Cheng Xin Rui-Li Guan

Published in: Andrology (2021)

YS-10, a novel synthesized flavonoid compound, could effectively improve erectile dysfunction in rats after BCNI by alleviating pathological impairments; this effect may associate with the upregulation of β-Catenin and cyclin D1 in Wnt signaling pathway.

Keyphrases

signaling pathway
cell proliferation
epithelial mesenchymal transition
cell cycle
pi k akt
stem cells
poor prognosis
induced apoptosis
peripheral nerve
endoplasmic reticulum stress
oxide nanoparticles