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Variants in urate transporters, ADH1B, GCKR and MEPE genes associate with transition from asymptomatic hyperuricaemia to gout: results of the first gout versus asymptomatic hyperuricaemia GWAS in Caucasians using data from the UK Biobank.

Gabriela Sandoval-PlataKevin MorganAbhishek Abhishek
Published in: Annals of the rheumatic diseases (2021)
The association of urate transporters with gout supports the central role of hyperuricaemia in its pathogenesis. Larger GWAS are required to identify if variants in inflammatory pathways contribute to progression from AH to gout.
Keyphrases
  • uric acid
  • copy number
  • metabolic syndrome
  • oxidative stress
  • genome wide
  • electronic health record
  • big data
  • gene expression
  • cross sectional
  • deep learning
  • transcription factor
  • genome wide association study