Variants in urate transporters, ADH1B, GCKR and MEPE genes associate with transition from asymptomatic hyperuricaemia to gout: results of the first gout versus asymptomatic hyperuricaemia GWAS in Caucasians using data from the UK Biobank.

Gabriela Sandoval-PlataKevin MorganAbhishek Abhishek

Published in: Annals of the rheumatic diseases (2021)

The association of urate transporters with gout supports the central role of hyperuricaemia in its pathogenesis. Larger GWAS are required to identify if variants in inflammatory pathways contribute to progression from AH to gout.

Keyphrases

uric acid
copy number
metabolic syndrome
oxidative stress
genome wide
electronic health record
big data
gene expression
cross sectional
deep learning
transcription factor
genome wide association study