Myocardial oxidative stress correlates with left ventricular dysfunction on strain echocardiography in a rodent model of sepsis.
Bereketeab HaileselassieErik SuIraklis PoziosDiego F NiñoHongyun LiuDai-Yin LuIoannis VentoulisWilliam B FultonChhinder P SodhiDavid HackamBrian O'RourkeTheodore AbrahamPublished in: Intensive care medicine experimental (2017)
In this sepsis model, SE identified cardiomyopathy despite normal EF. SE depression temporally coincides with upregulation of inflammatory cytokines and decreases expression of key mitochondrial ROS scavengers. Upregulation of redox scavenger (CAT) abrogates oxidative stress and cardiac dysfunction in this sepsis model.
Keyphrases
- oxidative stress
- left ventricular
- poor prognosis
- intensive care unit
- acute kidney injury
- dna damage
- heart failure
- septic shock
- diabetic rats
- ischemia reperfusion injury
- acute myocardial infarction
- cell death
- signaling pathway
- long non coding rna
- pulmonary hypertension
- coronary artery disease
- cardiac resynchronization therapy
- reactive oxygen species
- binding protein
- left atrial
- acute coronary syndrome
- aortic valve
- ejection fraction