Impact of risk factors for major cardiovascular diseases: a comparison of life-time observational and Mendelian randomisation findings.
Lars LindMartin IngelssonJohan SundstromJohan ÄrnlövPublished in: Open heart (2021)
By combining long-term observational data with genetic data, we show that the impact and causal role of specific established cardiovascular risk factors varies between different major CVDs. Systolic blood pressure was causally related to all four cardiovascular outcomes and was therefore, overall, the most important risk factor.
Keyphrases
- cardiovascular risk factors
- blood pressure
- cardiovascular disease
- electronic health record
- risk factors
- metabolic syndrome
- big data
- heart failure
- hypertensive patients
- left ventricular
- heart rate
- cross sectional
- genome wide
- gene expression
- data analysis
- machine learning
- coronary artery disease
- insulin resistance
- deep learning
- artificial intelligence
- atrial fibrillation