Impact of radiotherapy and sequencing of systemic therapy on survival outcomes in melanoma patients with previously untreated brain metastasis: a multicenter DeCOG study on 450 patients from the prospective skin cancer registry ADOREG.
Cindy FranklinPeter MohrLeonie BluhmImke GrimmelmannRalf GutzmerFriedegund MeierMarlene GarzarolliMichael WeichenthalClaudia PfoehlerRudolf HerbstPatrick TerheydenJochen UtikalJens UlrichDirk DebusSebastian HaferkampMartin KaatzAndrea ForschnerUlrike LeiterDorothee NashanAlexander KreuterMichael SachseJulia WelzelLucie HeinzerlingFrank MeissCarsten WeishauptThilo GambichlerGerhard WeyandtEdgar DippelKerstin SchattonEren CelikMaike TrommerIris HelfrichAlexander RoeschLisa ZimmerElisabeth LivingstoneDirk SchadendorfSusanne HornSelma UgurelPublished in: Journal for immunotherapy of cancer (2022)
In patients with MBM, the addition of radiotherapy resulted in a favorable OS on systemic therapy. In BRAF-mutated MBM patients, ICB as first-line therapy and BRAF+MEK as second-line therapy were associated with a significantly prolonged OS.