Language impairment in the genetic forms of behavioural variant frontotemporal dementia.
Kiran SamraAmy M MacDougallArabella BouziguesMartina BocchettaDavid M CashCaroline V GreavesRhian S ConveryJohn C van SwietenHarro SeelaarLize JiskootFermin MorenoRaquel Sanchez-ValleRobert LaforceCaroline GraffMario MasellisMaria Carmela TartagliaJames B RoweBarbara BorroniElizabeth FingerMatthis SynofzikDaniela GalimbertiRik VandenbergheAlexandre de MendonçaChristopher R ButlerAlexander GerhardSimon DucharmeIsabelle Le BerPietro TiraboschiIsabel SantanaFlorence PasquierJohannes LevinMarkus OttoSandro SorbiJonathan D RohrerLucy L Russellnull nullPublished in: Journal of neurology (2022)
Language deficits exist in a substantial proportion of people with familial bvFTD across all three genetic groups. Significant atrophy is seen in the dominant perisylvian language areas and correlates with language impairments within each of the genetic groups. Improved understanding of the language phenotype in the main genetic bvFTD subtypes will be helpful in future studies, particularly in clinical trials where accurate stratification and monitoring of disease progression is required.