Rapid Synthesis of Alkenylated BINOL Derivatives via Rh(III)-Catalyzed C-H Bond Activation.

Modification of BINOL units has been well examined via Rh-catalyzed C-H activation and functionalization reactions by using ester carbonyls as directing groups and alkenes as coupling partners. The one-pot strategy was an efficient protocol for the rapid synthesis of BINOL derivatives with retention of optical purity.