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Blood flow meets mitophagy.

Emir Bora AkmeriçHolger Gerhardt
Published in: The Journal of cell biology (2022)
Since its discovery as a mechanosensitive transcription factor in endothelial networks, Klf2's varying expression levels under different blood flow patterns remained a mystery. In this study, Coon et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202109144) discover a connection between sustained laminar shear stress and mitochondrial flux that contributes to Klf2's transcriptional dynamics.
Keyphrases
  • blood flow
  • transcription factor
  • poor prognosis
  • dna binding
  • single cell
  • oxidative stress
  • small molecule
  • gene expression
  • endothelial cells
  • high throughput
  • genome wide identification
  • long non coding rna
  • heat shock