The electrophysiologic effects of KCNQ1 extend beyond expression of IKs: evidence from genetic and pharmacologic block.

Yuko WadaLili WangLynn D HallTao YangLaura L ShortJoseph F SolusAndrew M GlazerDan M Roden

Published in: Cardiovascular research (2024)

Our data strongly suggest that KCNQ1 expression modulates baseline cardiac repolarization, and the response to IKr block, through mechanisms beyond simply generating IKs.

Keyphrases

poor prognosis
binding protein
left ventricular
genome wide
long non coding rna
heart failure
big data
copy number
dna methylation