Modulatory effects of photobiomodulation in the anterior cingulate cortex of diabetic rats.
Igor Rafael Correia RochaMarucia ChacurPublished in: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology (2021)
Anterior Cingulate Cortex (ACC) has a crucial contribution to higher order pain processing. Photobiomodulation (PBM) has being used as integrative medicine for pain treatment and for a variety of nervous system disorders. This study evaluated the effects of PBM in the ACC of diabetic rats. Type 1 diabetes was induced by a single dose of streptozotocin (85 mg/Kg). A total of ten sessions of PBM (pulsed gallium-arsenide laser, 904 nm, 9500 Hz, 6.23 J/cm2) was applied to the rat peripheral nervous system. Glial fibrillary acidic protein (GFAP), mu-opioid receptor (MOR), glutamate receptor 1 (GluR1), and glutamic acid decarboxylase (GAD65/67) protein level expression were analyzed in the ACC of diabetic rats treated with PBM. Our data revealed that PBM decreased 79.5% of GFAP protein levels in the ACC of STZ rats. Moreover, STZ + PBM rats had protein levels of MOR increased 14.7% in the ACC. Interestingly, STZ + PBM rats had a decrease in 70.7% of GluR1 protein level in the ACC. Additionally, PBM decreased 45.5% of GAD65/67 protein levels in the ACC of STZ rats.
Keyphrases
- diabetic rats
- oxidative stress
- type diabetes
- binding protein
- protein protein
- chronic pain
- functional connectivity
- amino acid
- pain management
- cardiovascular disease
- spinal cord
- poor prognosis
- neuropathic pain
- skeletal muscle
- single cell
- spinal cord injury
- small molecule
- artificial intelligence
- photodynamic therapy
- machine learning
- big data
- ionic liquid
- high fat diet
- adipose tissue
- replacement therapy
- network analysis