Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization.

Manisha DeoghariaLeslye Venegas-ZamoraAkanksha Agrawal Miusi ShiAbhinav K JainKevin J McHugh Francisco AltamiranoA J MarianPriyatansh Gurha

Published in: Cardiovascular research (2024)

KDM5 inhibition enhances maturation of iPSC-CMs by epigenetically upregulating the expressions of OXPHOS, FAO, and sarcomere genes and enhancing myofibril organization and mitochondrial function.

Keyphrases

fatty acid
dna methylation
genome wide
angiotensin ii
hydrogen peroxide
long noncoding rna
protein kinase
genome wide identification
gene expression
transcription factor
genome wide analysis