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Generation of populations of antigen-specific cytotoxic T cells using DCs transfected with DNA construct encoding HER2/neu tumor antigen epitopes.

Maria KuznetsovaJulia LopatnikovaJulia KhantakovaRinat MaksyutovAmir MaksyutovSergey V Sennikov
Published in: BMC immunology (2017)
The developed protocol improves the efficiency of obtaining HER2/neu-specific CTLs and can be further used to obtain cell-based vaccines for eradicating targeted tumor cells to prevent tumor recurrence after the major tumor burden has been eliminated and preventing metastasis in patients with HER2-overexpressing tumors.
Keyphrases
  • randomized controlled trial
  • single cell
  • stem cells
  • cell therapy
  • single molecule
  • cancer therapy
  • bone marrow
  • circulating tumor cells