Long-term ecological assessment of intracranial electrophysiology synchronized to behavioral markers in obsessive-compulsive disorder.
Nicole R ProvenzaSameer A ShethEvan M Dastin-van RijnRaissa K MathuraYaohan DingGregory S VogtMichelle Avendano-OrtegaNithya RamakrishnanNoam PeledLuiz Fernando Fracassi GelinDavid XingLaszlo A JeniItir Onal ErtugrulAdriel Barrios-AndersonEvan MattesonAndrew D WieseJunqian XuAshwin ViswanathanMatthew T HarrisonKelly R BijankiEric A StorchJeffrey F CohnWayne K GoodmanDavid A BortonPublished in: Nature medicine (2021)
Detection of neural signatures related to pathological behavioral states could enable adaptive deep brain stimulation (DBS), a potential strategy for improving efficacy of DBS for neurological and psychiatric disorders. This approach requires identifying neural biomarkers of relevant behavioral states, a task best performed in ecologically valid environments. Here, in human participants with obsessive-compulsive disorder (OCD) implanted with recording-capable DBS devices, we synchronized chronic ventral striatum local field potentials with relevant, disease-specific behaviors. We captured over 1,000 h of local field potentials in the clinic and at home during unstructured activity, as well as during DBS and exposure therapy. The wide range of symptom severity over which the data were captured allowed us to identify candidate neural biomarkers of OCD symptom intensity. This work demonstrates the feasibility and utility of capturing chronic intracranial electrophysiology during daily symptom fluctuations to enable neural biomarker identification, a prerequisite for future development of adaptive DBS for OCD and other psychiatric disorders.
Keyphrases
- deep brain stimulation
- obsessive compulsive disorder
- parkinson disease
- endothelial cells
- primary care
- physical activity
- patient reported
- gene expression
- stem cells
- big data
- dna methylation
- climate change
- electronic health record
- high intensity
- machine learning
- label free
- pluripotent stem cells
- genome wide
- mesenchymal stem cells
- brain injury
- subarachnoid hemorrhage
- induced pluripotent stem cells
- data analysis
- loop mediated isothermal amplification
- cerebral ischemia
- sensitive detection
- optical coherence tomography
- chemotherapy induced
- bioinformatics analysis