Impact of maternal protein restriction on Hypoxia-Inducible Factor (HIF) expression in male fetal kidney development.
Julia Seva GomesLeticia Barros SeneGabriela Leme LamanaPatricia Aline BoerJosé Antônio Rocha GontijoPublished in: PloS one (2023)
The current study supported that the programmed reduced nephron number in the 17-DG LP offspring may be related to changes in the HIF-1α signaling pathway. Factors that facilitate the transposition of HIF-1α to progenitor renal cell nuclei, such as increased NOS, Ep300, and HSP90 expression, may have a crucial role in this regulatory system. Also, HIF-1α changes could be associated with reduced transcription of elF-4 and its respective signaling path.
Keyphrases
- poor prognosis
- endothelial cells
- signaling pathway
- binding protein
- transcription factor
- heat shock protein
- epithelial mesenchymal transition
- cell therapy
- type diabetes
- heat shock
- birth weight
- body mass index
- nitric oxide
- stem cells
- oxidative stress
- pregnant women
- mesenchymal stem cells
- cell proliferation
- heat stress
- insulin resistance
- protein protein