Effects of sarcopenia and sarcopenic obesity on joint pain and degenerative osteoarthritis in postmenopausal women.
Hye In KimSo Hyun AhnYup KimJi Eun LeeEuna ChoiSeok Kyo SeoPublished in: Scientific reports (2022)
This study aimed to identify the prevalence of sarcopenia, obesity, and sarcopenic obesity and examine their association with radiographic knee osteoarthritis (OA) and knee pain in Korean postmenopausal women. This cross-sectional study utilized the data from Korean National Health and Nutrition Examination Surveys 2009-2011. The participants were categorized into 4 groups based on body composition: either sarcopenic (appendicular skeletal muscle < 23%) or not, either obese (body mass index ≥ 25.0 kg/m 2 ) or not. The prevalence of radiographic knee OA and knee pain was calculated. The effect of hormone replacement therapy (HRT) was also evaluated. The prevalence of radiographic knee OA, knee pain, and both were all highest in the sarcopenic obese group and lowest in the control group (61.49% vs. 41.54%, 39.11% vs. 27.55%, 32.04% vs. 17.82%, all p < 0.001). Without sarcopenia, obese women showed significantly higher ratio of radiographic knee OA only (57.64% vs. 41.54%, p < 0.001). With sarcopenia, the coexistence of obesity presented higher ratio of radiographic knee OA, knee pain, and both compared to sarcopenia without obesity (61.49% vs. 41.82%, 39.11% vs. 27.61%, 32.04% vs. 17.60%, all p < 0.001). The use of HRT for more than 1 year was not associated with radiographic knee OA, knee pain, or both (p = 0.147, 0.689 and 0.649, respectively). Obesity with sarcopenia had greater effect on knee OA compared to obesity without sarcopenia. Moreover, HRT use for more than 1 year was not associated with the prevalence of knee OA. Therefore, more efforts should focus on reducing body fat and increasing muscle in postmenopausal women with knee OA.
Keyphrases
- knee osteoarthritis
- skeletal muscle
- total knee arthroplasty
- weight loss
- insulin resistance
- metabolic syndrome
- postmenopausal women
- type diabetes
- chronic pain
- body composition
- bone mineral density
- body mass index
- weight gain
- anterior cruciate ligament
- high fat diet induced
- adipose tissue
- pain management
- neuropathic pain
- anterior cruciate ligament reconstruction
- bariatric surgery
- risk factors
- replacement therapy
- polycystic ovary syndrome
- community dwelling
- rheumatoid arthritis
- cross sectional
- machine learning
- pregnant women
- high intensity
- spinal cord injury
- cervical cancer screening
- pregnancy outcomes