Varicella-zoster virus proteome-wide T-cell screening demonstrates low prevalence of virus-specific CD8 T-cells in latently infected human trigeminal ganglia.
Michiel Van GentWerner J D OuwendijkVictoria L CampbellKerry J LaingGeorges G M G M VerjansDavid M KoellePublished in: Journal of neuroinflammation (2023)
The low presence of VZV- compared to HSV-1-specific CD8 T-cells in human TG suggests that VZV reactive CD8 T-cells play a limited role in maintaining VZV latency.