Cerebral Microvascular Injury in Severe COVID-19.
John ConklinMatthew P FroschShibani S MukerjiOtto RapalinoMary MaherPamela W SchaeferMichael H LevRamon Gilberto GonzálezSudeshna DasSamantha N ChampionColin MagdamoPritha SenGeorge Kyle HarroldHaitham AlabsiErica NormandinBennett M ShawJacob E LemieuxPardis C SabetiJohn A BrandaEmery N BrownMichael Brandon WestoverSusie Y HuangBrian L EdlowPublished in: medRxiv : the preprint server for health sciences (2020)
SWI lesions are common in patients with neurological manifestations of severe COVID-19 (coma and focal neurologic deficits). The distribution of lesions is similar to that seen in patients with hypoxic respiratory failure, sepsis, and disseminated intravascular coagulation. Collectively, these radiologic and histopathologic findings suggest that patients with severe COVID-19 are at risk for multifocal microvascular hemorrhagic and ischemic lesions in the subcortical and deep white matter.