Randomised trials conducted using cohorts: a scoping review.

Beverley Jane NickollsClare ReltonLars G HemkensMerrick ZwarensteinSandra EldridgeStephen J McCall Xavier Luke GriffinRatna SohanpalHelena M VerkooijenJonathon L MaguireKimberly A McCord

Published in: BMJ open (2024)

This review outlines the development of cohorts to conduct RCTs including the range of use and innovative changes and adaptations. Inconsistencies in the use of terminology and concepts are highlighted. Guidance now needs to be developed to support the design and reporting of RCTs conducted using cohorts.

Keyphrases

clinical trial
open label
study protocol
high intensity
randomized controlled trial
double blind
adverse drug
placebo controlled
electronic health record