Effect modification in network meta-analyses for relapsed/refractory multiple myeloma: systematic review and meta-analysis.
Patricia Sofia Jacobsen JardimIngrid Kristine OhmLiv GiskeGunn Eva NæssAtle FretheimPublished in: BMJ open (2023)
Based on the available evidence, effect modification appears to be sufficiently small that it can be neglected in adequately performed NMAs. NMAs can probably be relied on to provide estimates of HRs for OS and PFS in RRMM, subject to caveats discussed herein.