Unique expansion of IL-21+ Tfh and Tph cells under control of ICOS identifies Sjögren's syndrome with ectopic germinal centres and MALT lymphoma.

Elena Pontarini William James Murray-Brown Cristina Croia Davide Lucchesi James P Conway Felice Rivellese Liliane Fossati-JimackElisa AstorriEdoardo Prediletto Elisa Corsiero Francesca Romana Delvecchio Rachel ColebyEva GelbhardtAurora BonoChiara Baldini Ilaria Puxeddu Roberto Caporali Roberto Giacomelli Francesca Barone Benjamin A Fisher Simon J Bowman Serena Colafrancesco Roberta Priori Nurhan SutcliffeStephen ChallacombeGianluca Carlesso Anwar R Tappuni Costantino Pitzalis Michele Bombardieri

Published in: Annals of the rheumatic diseases (2020)

Overall, these findings highlight Tfh and Tph-cells, IL-21 and the ICOS costimulatory pathway as key pathogenic players in SS immunopathology and exploitable therapeutic targets in SS.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
signaling pathway
cell death
oxidative stress
genome wide
case report
pi k akt