Organic electronics for high-resolution electrocorticography of the human brain.
Dion KhodagholyJennifer N GelinasZifang ZhaoMalcolm YehMichael LongJeremy D GreenleeWerner K DoyleOrrin DevinskyGyörgy BuzsákiPublished in: Science advances (2016)
Localizing neuronal patterns that generate pathological brain signals may assist with tissue resection and intervention strategies in patients with neurological diseases. Precise localization requires high spatiotemporal recording from populations of neurons while minimizing invasiveness and adverse events. We describe a large-scale, high-density, organic material-based, conformable neural interface device ("NeuroGrid") capable of simultaneously recording local field potentials (LFPs) and action potentials from the cortical surface. We demonstrate the feasibility and safety of intraoperative recording with NeuroGrids in anesthetized and awake subjects. Highly localized and propagating physiological and pathological LFP patterns were recorded, and correlated neural firing provided evidence about their local generation. Application of NeuroGrids to brain disorders, such as epilepsy, may improve diagnostic precision and therapeutic outcomes while reducing complications associated with invasive electrodes conventionally used to acquire high-resolution and spiking data.
Keyphrases
- high resolution
- high density
- cerebral ischemia
- resting state
- white matter
- randomized controlled trial
- mass spectrometry
- functional connectivity
- water soluble
- spinal cord
- risk factors
- electronic health record
- subarachnoid hemorrhage
- type diabetes
- patients undergoing
- blood brain barrier
- multiple sclerosis
- deep brain stimulation
- tandem mass spectrometry
- high speed
- genetic diversity
- spinal cord injury
- gold nanoparticles
- reduced graphene oxide
- metabolic syndrome
- adipose tissue
- skeletal muscle
- liquid chromatography
- insulin resistance
- deep learning
- data analysis