Evaluation of molecular effects associated with apoptosis, tumour progression, angiogenesis and metastasis by a novel combination of drugs with ormeloxifene in triple negative breast cancer cells.

Shehna Sharaf Sreelekshmi S Saikant Regidi Abi Santhosh ApremRajmohan GopimohanLakshmi S

Published in: Exploration of targeted anti-tumor therapy (2024)

Collectively this study reveals the efficacy of Orm + comb as more significant than the clinically used tamoxifen (Tam). The study elucidates the promising novelty of the combination as a potential chemotherapeutic intervention for mitigating the aggressiveness of triple negative breast cancer and it addresses the intrinsic resistance caused by single drug treatments.

Keyphrases

cell proliferation
breast cancer cells
randomized controlled trial
oxidative stress
emergency department
risk assessment
vascular endothelial growth factor
drug induced
estrogen receptor