Comparison Of drrA And drrB Efflux Pump Genes Expression In Drug-Susceptible And -Resistant Mycobacterium tuberculosis Strains Isolated From Tuberculosis Patients In Iran.
Azar Dokht KhosraviMehrandokht SirousZahra AbsalanMohammad Reza TabandehMohammad SavariPublished in: Infection and drug resistance (2019)
The results of the present study confirm the role of DrrA-DrrB efflux pump in antibiotic resistance in clinical MTB isolates. As the large number of efflux pumps are located in the cell envelope of MTB, we cannot correlate a single efflux pump overexpression to the drug-resistance phenotype, unless all the pumps simultaneously investigated.
Keyphrases
- mycobacterium tuberculosis
- pulmonary tuberculosis
- end stage renal disease
- poor prognosis
- newly diagnosed
- ejection fraction
- chronic kidney disease
- escherichia coli
- prognostic factors
- stem cells
- genome wide
- single cell
- cell proliferation
- cell therapy
- emergency department
- gene expression
- bone marrow
- hepatitis c virus
- mesenchymal stem cells
- binding protein
- drug induced
- human immunodeficiency virus
- long non coding rna
- hiv aids
- patient reported