(DiMeIHeptCl)Pd: A Low-Load Catalyst for Solvent-Free (Melt) Amination.
Volodymyr SemeniuchenkoSepideh SharifJonathan DayNalin ChandrasomaWilliam J PietroJeffrey ManthorpeWilfried M BrajeMichael G OrganPublished in: The Journal of organic chemistry (2021)
(DiMeIHeptCl)Pd, a hyper-branched N-aryl Pd NHC catalyst, has been shown to be efficient at performing amine arylation reactions in solvent-free ("melt") conditions. The highly lipophilic environment of the alkyl chains flanking the Pd center serves as lubricant to allow the complex to navigate through the paste-like environment of these mixtures. The protocol can be used on a multi-gram scale to make a variety of aniline derivatives, including substrates containing alcohol moieties.