Expression Profiling of Circular RNAs in Early Pregnant Jianghuai Buffaloes.
Qiuchen LiuMengya ZhangTenglong GuoSucheng WuYanfeng ZongChangzhi XuZhihua ZhuYun-Hai ZhangZu-Bing CaoPublished in: Animals : an open access journal from MDPI (2022)
Circular RNA (circRNA) is expressed in cells and tissues of several species. However, the expression of circRNAs in the blood of Jianghuai buffaloes during early pregnancy has not been reported. In this study, we identified the DECs in the blood of Jianghuai buffaloes and annotated the functions of these DECs. The results showed that there were 890 DECs between the pregnant and non-pregnant groups, of which more than 80% were exon-derived circRNAs, including 323 up-regulated circRNAs and 567 down-regulated circRNAs. Enrichment analysis revealed that DECs were mainly enriched in the epidermal growth factor receptor-signaling pathway important for embryonic development and pregnancy maintenance. In addition, most DECs have multiple miRNA targets, suggesting that these DECs have the potential to function as miRNA sponges. In conclusion, several DECs are present between pregnant and non-pregnant Jianghuai buffaloes, and these DECs are associated with embryo implantation and pregnancy establishment.
Keyphrases
- epidermal growth factor receptor
- pregnant women
- signaling pathway
- pregnancy outcomes
- induced apoptosis
- tyrosine kinase
- transcription factor
- poor prognosis
- preterm birth
- gene expression
- advanced non small cell lung cancer
- epithelial mesenchymal transition
- oxidative stress
- cell cycle arrest
- pi k akt
- cell death
- risk assessment
- human health
- data analysis