Spatially Distinct Reprogramming of the Tumor Microenvironment Based On Tumor Invasion in Diffuse-Type Gastric Cancers.

Hye Young JeongIn-Hye HamSung Hak LeeDaeun RyuSang-Yong SonSang-Uk HanTae-Min KimHoon Hur

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

This study reveals the spatial reprogramming of the TME that may underlie invasive tumor potential in diffuse-type gastric cancer. This TME profiling across tumor layers suggests new targets, such as CCL2, that can modify the TME to inhibit tumor progression in diffuse-type gastric cancer.See related commentary by Huang and Brekken, p. 6284.

Keyphrases

low grade
poor prognosis
climate change
long non coding rna
high grade