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Dynamic rewiring of the human interactome by interferon signaling.

Craig H KerrMichael A SkinniderDaniel D T AndrewsAngel M MaderoQueenie W T ChanR Greg StaceyNikolay StoynovEric JanLeonard J Foster
Published in: Genome biology (2020)
Our map of the IFN interactome provides a global view of the complex cellular networks activated during the antiviral response, placing IFN-stimulated genes in a functional context, and serves as a framework to understand how these networks are dysregulated in autoimmune or inflammatory disease.
Keyphrases
  • dendritic cells
  • immune response
  • endothelial cells
  • multiple sclerosis
  • oxidative stress
  • induced pluripotent stem cells
  • genome wide
  • pluripotent stem cells
  • high density
  • dna methylation