Effect of intra-arrest transport, extracorporeal cardiopulmonary resuscitation and immediate invasive assessment in refractory out-of-hospital cardiac arrest: a long-term follow-up of the Prague OHCA trial.
Daniel RobKlaudia FarkasovskaMarketa KreckovaOndrej SmidPetra KavalkovaJaromir MacounMichal HuptychPetra HavrankovaJuraj GalloJan PudilMilan DusikStepan HavranekAles LinhartJan BelohlávekPublished in: Critical care (London, England) (2024)
Among patients with refractory OHCA, the ECPR-based approach significantly improved long-term survival. There were no differences in the neurological outcome, major cardiovascular events and quality of life between the groups, but the trial was possibly underpowered to detect a clinically relevant difference in these outcomes. Trial registration ClinicalTrials.gov Identifier: NCT01511666, Registered 19 January 2012.
Keyphrases
- cardiopulmonary resuscitation
- cardiovascular events
- cardiac arrest
- phase iii
- study protocol
- phase ii
- clinical trial
- coronary artery disease
- cardiovascular disease
- randomized controlled trial
- open label
- cell cycle
- adipose tissue
- insulin resistance
- cell proliferation
- brain injury
- skeletal muscle
- double blind
- subarachnoid hemorrhage
- clinical evaluation