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Inhibition of CD226 Co-Stimulation Suppresses Diabetes Development in the NOD Mouse by Augmenting Tregs and Diminishing Effector T Cell Function.

Matthew E BrownPuchong ThirawatananondLeeana D PetersElizabeth J KernSonali VijayLindsey K SachsAmanda L PosgaiMaigan A BruskoMelanie R ShapiroClayton E MathewsRhonda BacherTodd M Brusko
Published in: bioRxiv : the preprint server for biology (2024)
CD226 blockade could reduce autoreactive T cell cytotoxicity, enhance Treg function, and slow disease progression in high-risk or recent-onset type 1 diabetes cases.
Keyphrases
  • type diabetes
  • glycemic control
  • cardiovascular disease
  • nk cells
  • signaling pathway
  • dendritic cells
  • insulin resistance
  • metabolic syndrome