Anwuligan inhibits the progression of non-small cell lung cancer via let-7c-3p/PI3K/AKT/mTOR axis.

Huikun NiuDexiang WangTingting WenHan LiuJing JieLei SongDan Li

Published in: Cancer medicine (2022)

In summary, ANW inhibits the growth and metastasis of NSCLC cells in vivo and in vitro by upregulating the expression of let-7c-3p, which can regulate the PI3K/AKT/mTOR signaling pathway. PIK3CA is the main target of let-7c-3p.

Keyphrases

induced apoptosis
signaling pathway
small cell lung cancer
poor prognosis
cell cycle arrest
pi k akt
endoplasmic reticulum stress
oxidative stress
advanced non small cell lung cancer
cell death
cell proliferation
protein kinase
brain metastases